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1996-02-27
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Document 0350
DOCN M9630350
TI Diverse immunological and hematological effects of interleukin 7:
implications for clinical application.
DT 9603
AU Komschlies KL; Grzegorzewski KJ; Wiltrout RH; Biological Carcinogenesis
and Development Program, SAIC; Frederick, National Cancer
Institute-Frederick Cancer Research; and Development Center, MD
21702-1201, USA.
SO J Leukoc Biol. 1995 Dec;58(6):623-33. Unique Identifier : AIDSLINE
MED/96107354
AB Interleukin-7 (IL-7) was originally discovered to be a pre-B cell growth
factor. Soon thereafter, a broader role for IL-7 in leukocyte
development and function began to be identified. IL-7 now has been shown
to be a critical cytokine for normal T and B lymphopoiesis and a
mobilizer of pluripotent stem cells and myeloid progenitors. IL-7 has
been demonstrated to enhance T cell function and induce cytokine
expression in monocytes. Preclinical studies have already found that
IL-7 could accelerate murine lymphocyte regeneration following
chemotherapy and bone marrow transplantation, induce antitumor effects
in mice, and expand anti-HIV-specific human T cells. Thus it is
essential that further preclinical and clinical research be performed to
evaluate IL-7 as a potential therapy for leukopenia, bone marrow/stem
cell transplantation, cancer, and HIV/AIDS.
DE Acquired Immunodeficiency Syndrome/THERAPY Animal Antigens,
CD/PHYSIOLOGY Cell Differentiation Hematopoiesis Human
Interleukin-7/*PHYSIOLOGY/THERAPEUTIC USE Mice Neoplasms/THERAPY
Receptors, Interleukin/PHYSIOLOGY T-Lymphocytes/PHYSIOLOGY JOURNAL
ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).